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Providing you the best range of ledikast, pemnat, myhep lvir tablet and myhep with effective & timely delivery.

Ledikast

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Ledikast
  • Ledikast
  • Ledikast
  • Ledikast
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Approx. Rs 18,500 / BottleGet Latest Price

Product Details:
CompanyAprazer Healthcare
Power (Mg)90mg and 400mg
Form Of MedicinesTablets
Packing Size28 Tablets
Dosage FormTablets
Packaging Size28 Tablets
Dose Or Strength (Mg)90mg and 400mg
GenericLedipasvir and Sofosbuvir
ManufacturerNatco Pharma Limited

Each film-coated tablet Contains:

Ledipasvir 90 mg

Sofosbuvir 400 mg

Colors: Yellow oxide of Iron, Titanium Dioxide IP and FD&C Blue#2

Ledikast is a fixed-dose combination tablet containing ledipasvir and sofosbuvir for oral administration. Ledipasvir is an HCV NS5A inhibitor and sofosbuvir is a nucleotide analog inhibitor of HCV NS5B polymerase.

Each film-coated tablet contains 90 mg ledipasvir and 400 mg sofosbuvir. The tablet includes the following inactive ingredients: colloidal silicon dioxide, copovidone, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. The tablet is film-coated with a coating material containing the following inactive ingredients: Yellow Oxide of Iron, polyethylene glycol, polyvinyl alcohol, talc, FD&C Blue #2 and titanium dioxide IP.

Ledipasvir: The IUPAC name for ledipasvir is Methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2azabicyclo[2.2.1] hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4] hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate.

2.0 CLINICAL PHARMACOLOGY

2.1 Mechanism of Action

Ledikast is a fixed-dose combination of ledipasvir and sofosbuvir which are directacting antiviral agents against the hepatitis C virus.

2.2 Pharmacodynamics

Cardiac Electrophysiology

Ledipasvir at a dose of 120 mg twice daily (2.67 times the maximum recommended dosage) and sofosbuvir 400 mg (maximum recommended dosage) and 1200 mg (three times the maximum recommended dosage) does not prolong QTc in clinical trials.

ADVERSE REACTIONS

9.1 Clinical Trials Experience

The most common adverse reactions (≥10%) were fatigue and headache in subjects treated with 8, 12, or 24 weeks of Ledikast. Table 2 lists adverse reactions (adverse events assessed as causally related by the investigator, all grades) observed in ≥5% of subjects receiving 8, 12, or 24 weeks treatment with Ledipasvir + Sofosbuvir in clinical trials. The majority of adverse reactions presented in Table 2 occurred at severity of grade 1. The side-by-side tabulation is to simplify presentation; direct comparison across trials should not be made due to differing trial designs.

Drugs without Clinically Significant Interactions with Ledikast

Based on drug interaction studies conducted with individual drugs Ledipasvir or Sofosbuvir or combination of Ledipasvir + Sofosbuvir, no clinically significant drug interactions have either been observed or are expected when Ledipasvir + Sofosbuvir is used with the following drugs individually: abacavir, atazanavir/ritonavir, cyclosporine, darunavir/ ritonavir, efavirenz, emtricitabine, lamivudine, , oral contraceptives, pravastatin, raltegravir, rilpivirine, tacrolimus, tenofovir disoproxil fumarate, or verapamil. See Table 3 for use of Ledikast with certain HIV antiretroviral regimens.

12.0 OVERDOSAGE

No specific antidote is available for overdose with Ledikast. If overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose with Ledikast consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient. Hemodialysis is unlikely to result in significant removal of ledipasvir since ledipasvir is highly bound to plasma protein. Hemodialysis can efficiently remove the predominant circulating metabolite of sofosbuvir, GS-331007, with an extraction ratio of 53%.

13.0 HOW SUPPLIED/STORAGE AND HANDLING

Ledikast tablets are Green colored, oval shaped and film-coated. 28 tablets packed in a bottle. One bottle and one literature housed in a carton.

Store below 30°C.



Additional Information:

  • Delivery Time: 1 To 2 Days
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Pemnat

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Pemnat
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Approx. Rs 15,000 / BottleGet Latest Price

Product Details:
Dose500 mg
Form of MedicineInjection
BrandNatco
UsagePersonal

WHAT IS PEMNAT ?

Pemnat 500mg is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. It is classified as an "antimetabolite". Premetrexed belongs to the class of chemotherapy drugs called antimetabolites. Antimetabolites are very similar to normal substances within the cell. When the cells incorporate these substances into the cellular metabolism, they are unable to divide. Antimetabolites are cell-cycle specific. They attack cells at very specific phases in the cycle.

MEDICINE USES :

Natco Pemetrexed is used in the treatment of malignant mesothelioma and Locally advanced or metastatic nonsquamous nonsmall cell lung cancer.

PEMETREXED COMMON SIDE EFFECTS :

tired feeling, loss of appetite, weight loss; upset stomach, nausea, vomiting, diarrhea; mild rash; or hair loss.

Call your doctor at once if you have:

  • severe ongoing vomiting or diarrhea; bone marrow suppression--fever, swollen gums, painful mouth sores, cold or flu symptoms, sore throat, pale skin, easy bruising or bleeding, skin sores, red or pink urine, rapid heart rate, feeling light-headed or short of breath,
  • kidney problems--swelling, rapid weight gain, little or no urinating; signs of dehydration--feeling very thirsty or hot, being unable to urinate, heavy sweating, hot and dry skin; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical



Additional Information:

  • Delivery Time: 5 To 10 Days
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MyHep LVIR Tablet

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MyHep LVIR Tablet
  • MyHep LVIR Tablet
  • MyHep LVIR Tablet
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Approx. Rs 10,000 / BottleGet Latest Price

Product Details:
Strength/Dose (in mg or ml)90 mg,400 mg

With the consistent efforts of our ingenious professionals, we are fulfilling the diverse requirements of our clients by exporting, retailing, wholesaling and supplying qualitative MyHep LVIR Tablet.

Processed using high grade chemical compounds and innovative technology at our ultra-modern production unit, offered tablet reduces the amount of HCV in the body by preventing the spread of the HCV within the body. The provided tablet is tested under the guidance of our quality examiners on different quality parameters like purity and effectiveness.

Features:


  • Long shelf life
  • Hygienically packed
  • Accurate composition

Specifications:

 

  • Brand Name: Mylan
  • Contain: Sofosbuvir 400mg
  • Packaging Type 28 Tablets


Additional Information:

  • Delivery Time: 10 to 14 days
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Myhep

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Myhep
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Approx. Rs 8,000 / BottleGet Latest Price

Product Details:
Strength/Dose (in mg or ml)400 mg
Pack Size28 tablets
Product TypeFinish Product

MyHep contains the active ingredient Sofosbuvir. It is a generic brand of anti-viral medication used to treat Hepatitis C virus. MyHep is manufactured by Mylan Pharmaceuticals. Sofosbuvir can help the immune system and the liver recover from a Hepatitis C infection.

Specifications:
  • Active Ingredients: Sofosbuvir
  • Manufacturer: Mylan
  • Use: In liver infection

MOQ 28 Tab

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