Approx. Rs 15,000 / BottleGet Latest Price
Product Details:Dosage Form (If Applicable) | Tablets |
Dose | 400 mg |
Brand | Sofokast |
Packing | 28 Tablets |
Generic Name | Sofosbuvir |
Company | Aprazer Healthcare |
The medicinal product “Sofoskast” is treated with a chronic form of Hepatitis C. Complex therapy with the use of this drug and other medications are prescribed for adult patients. The drug also treats patients with HIV and co-infections. The active component of the Sofokast tablets is sofosbuvir. They are coated and contain 400 mg of the basic substance. The package contains 28 tablets.
Indications for use of the drug
The drug “Sofosbuvir 400mg” is prescribed for patients with hepatitis C when the disease has passed into a chronic form. A combined approach is used for the effectiveness of treatment. It is possible to use medicament in cases when the patient has HIV in addition to hepatitis.
Contraindications to taking the drug “Sofosbuvir”
The drug is not used for hypersensitivity to substances that are present in its composition. Despite the fact that the drug does not affect fertility, it is rarely prescribed to women in their reproductive years. The use of the drug during pregnancy and breastfeeding is not recommended, as it can be harmful to the child. When pregnancy occurs, the combination of Sofosbuvir with such drugs as Interferon alfa and Ribavirin may have a negative effect on its course. For this reason, during the period of treatment, the child’s bearing is undesirable. The experiments, during which the drug “buy sofosbuvir online” was tested in animals, showed that this drug has a slightly negative impact on the offspring. Before you start taking it, you should carefully study the instructions for the drug and consult with a specialist.
Side Effect
Additional Information:
Approx. Rs 17,500 / BottleGet Latest Price
Product Details:Generic Name | Velpatasvir and Sofosbuvir |
Packaging Type | Bottles |
Dose | 100mg-400mg |
Packing Size | 28 Tablets |
Strength (mg) | 100mg and 400mg |
Company | Aprazer Healthcare |
Dose Or Strength (Mg) | 100mg and 400mg |
Manufacturer | Natco Pharma Limited |
VELAKAST TABLETS
VELAKAST is a fixed-dose combination tablet containing sofosbuvir and velpatasvir for oral administration. Sofosbuvir is a nucleotide analog HCV NS5B polymerase inhibitor and velpatasvir is an NS5A inhibitor. Each tablet contains 400 mg sofosbuvir and 100 mg velpatasvir. The tablets include the following inactive ingredients: copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The tablets are film-coated with a coating material containing the following inactive ingredients: Titanium Dioxide IP and Brilliant Blue FCF, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.
Effect of the drug
Thanks to the powerful composition of the drug, Velakast APRAZER HEALTHCARE is widely used to fight the hepatitis C virus of genotypes 1-6. The drug may be given as a monotherapy or for combined treatment with or without cirrhosis. The high effectiveness of the drug against all genotypes of HCV is due to the presence in its composition:
Sofosbuvir: The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5(2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran- 2yl)methoxy (phenoxy)phosphorylamino)propanoate. It has a molecular formula of C22H29FN3 O9 P and a molecular weight of 529.45. Sofosbuvir is a white to off-white crystalline solid with a solubility of at least 2 mg/mL across the pH range of 2–7.7 at 37°C and is slightly soluble in water.
Velpatasvir: The IUPAC name for velpatasvir is Methyl {(1R)-2-[(2S,4S)-2-(5-{2[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl) amino]-3-methylbutanoyl}-5-methylpyrrolidin-2-yl]1,11-dihydro[2]benzopyrano[4′,3′:6,7]naphtho[1,2-d]imidazol-9- yl}-1H-imidazol-2-yl)-4(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate. It has a molecular formula of C49H54 N8 O8 and a molecular weight of 883.0. Velpatasvir is practically insoluble (less than 0.1 mg/mL) above pH 5, slightly soluble (3.6 mg/mL) at pH 2, and soluble (greater than 36 mg/mL) at pH 1.2.
Mechanism of Action
VELAKAST is a fixed-dose combination of sofosbuvir and velpatasvir which are direct-acting antiviral agents against the hepatitis C virus Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. In a biochemical assay, GS-461203 inhibited the polymerase activity of the recombinant NS5B from HCV genotype 1b, 2a, 3a and 4a with an IC50 value ranging from 0.36 to 3.3 micromolar. GS-461203 is neither an inhibitor of human DNA and RNA polymerases nor an inhibitor of mitochondrial RNA polymerase. Velpatasvir is an inhibitor of the HCV NS5A protein, which is required for viral replication. Resistance selection in cell culture and cross-resistance studies indicates velpatasvir targets NS5A as its mode of action.
OVERDOSAGE
No specific antidote is available for overdose with VELAKAST. If overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose with VELAKAST consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient. Hemodialysis can efficiently remove the predominant circulating metabolite of sofosbuvir, GS-331007, with an extraction ratio of 53%. Hemodialysis is unlikely to result in significant removal of velpatasvir since velpatasvir is highly bound to plasma protein.
HOW SUPPLIED AND STORAGE
Each bottle contains 28 tablets and is closed with a child-resistant closure. Storage: Store below 30°C
Additional Information:
Approx. Rs 2,100 / BottleGet Latest Price
Product Details:Form Of Medicines | Tablets |
Brand | Sun Pharma |
Daclafab 60mg tablets?
Daclafab is an innovative antiviral drug. The active substance Daclatasvir (60
mg) is an inhibitor of the nonstructural protein 5A (NS5A). The drug is used with an NS5Binhibitor, so Daclafab buy in Moscow is recommended in combination with Sofosbuvir.
Daclafab is a licensed generic drug. It is produced by several
pharmaceutical companies, including Natco Pharma (India), accordingly the price of Daclatasvir may
vary.
Description?
Daclafab is an inhibitor of the viral (hepatitis C virus) protein NS5A, which is used in the replication of hepatitis C virus within the liver cells (hepatocytes) and, thus, prevents the virus from entering infected hepatocytes into the blood. Thanks to this action, it is possible to prevent the spread of the virus in the body.
Daclafab (Daclatasvir) is a highly specific direct action agent against hepatitis C virus (HCV) and does not have a pronounced activity against other RNA and DNA containing viruses, including human immunodeficiency virus (HIV).
Daclafab (Daclatasvir) is an inhibitor of the non-structural protein 5A (NS5A), a multifunctional protein required for HCV replication, and thus suppresses two stages of the life cycle of the virus-viral RNA replication and virion assembly.
Based on in vitro data and computer simulation data, it has been shown that Daclatasvir interacts with the N-terminus within domain 1 of the protein, which can cause structural distortions that interfere with the function of the NS5A protein.
It was found that the preparation is a potent phenotypic inhibitor of the hepatitis C virus replication of the genotypes 1a, 1b, 2a, 3a, 4a, 5a and 6a with effective concentrations (50% reduction, EC50) from picomolar to low nanomolar.
INDICATIONS FOR USE?
Treatment of chronic hepatitis C in patients with compensated liver disease
(including cirrhosis) in the following combinations of Daclatasvir:
- with the preparation of Sofosbuvir for patients with the hepatitis virus of genotypes 1, 3, 4, 5;
- with the drug asunaprevir for patients with the hepatitis virus of genotype 1b;
- with drugs asunaprevir, peginterferon alfa, and ribavirin - for patients with the
hepatitis virus of genotype 1.
DOSAGE AND ADMINISTRATION?
The recommended dose of Daclafab (Daclatasvir) is 60 mg once daily, regardless of food
intake. The drug should be used in combination with other medicines. Therapy is recommended for patients who have not previously received treatment for chronic hepatitis C, and with the previous ineffectiveness of therapy.
STORAGE CONDITIONS?
At a temperature not exceeding 30 ° C.
Additional Information:
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