BUY CANCER MEDICINES IN INDIA

Sorafenib 200mg is used to treat kidney, liver, and thyroid cancer. It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

How to use Sorafenib 200mg Tablet - 

Read the Patient Information Leaflet if available from your pharmacist before you start taking sorafenib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Abirapro 250 mg (Abiraterone acetate) belongs to a group of hormonal therapeutics utilized against prostate cancer in adults. Abirapro 250 mg (Abiraterone acetate) is indicated in prostate cancer patients wherein other chemotherapeutic options have failed. Additionally, it is specified in asymptomatic patients where other hormonal therapies were unsuccessful and chemotherapy was not employed.

Abirapro 250 mg (Abiraterone acetate) targets the unnecessary production of testosterone (a male hormone) used in cancer cell growth. It inhibits the testosterone triggering proteins (CYP17A1 enzyme), thereby decreasing the cancer toll on the body. Abirapro 250 mg (Abiraterone acetate) is administered orally without food. 4 tablets of 250 mg (1000 mg) once daily are taken along with 5 mg prednisone twice daily. When used together, Abirapro 250 mg (Abiraterone acetate) impart advantages like,

1. Lowers the antigen growth that stimulates prostate cancer.
2. Keeps prostate cancer under control.
3. Rectifies hypertension as a side-effect.
4. Induces hunger for a stable diet.
5. Increases duration of life-span.
6. Delays or rectifies common symptoms such as pain and tiredness.

 

Other Details:

• Sorafenat (sorafenib) is a cancer (chemotherapeutic) medication
• Sorafenat interfere with the growth and spread of cancer cells in the body
• Sorafenat is used to treat a type of kidney cancer called advanced renal cell carcinoma
• It is also used to treat liver cancer
• Sorafenat may also be used for purposes not listed in this medication guide

Other Details:

• Abiraterone Acetate is a drug used in combination with prednisone in metastatic castration-resistant prostate cancer (formerly hormone-resistant prostate cancer) which is a prostate cancer not responding to androgen deprivation or treatment with anti-androgens

Other Details:

• The medicine is processed with the use of gefitinib and basically belongs to a class of anti-cancer medications known as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
• Geftinat is widely consumed for the treatment of non-small cell lung cancer
• This medicine effectively blocks the activity of chemicals, which increases the growth of cancer cells

• Delivery Time: 10 to 14 days

Other Details:

• It contains Drug / Molecules called “Erlotinib”
• It belongs to Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors
• The medication works by interfering with the protein epidermal growth factor to prevent it from activating enzymes, cancer cells require these to multiply, grow and spread

Indication:

• Erlonat is used for the treatment of advance or metastatic Non-Small Cell Lung cancer

• Delivery Time: 7 to 14 Days

Veenat includes imatinib and is a world class medicine known as protein-tyrosine kinase inhibitor. 

Veenat is an effective medication for curing leukemia (chronic myeloid leukemia or cml) and gastrointestinal stromal tumors (gists - a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body). Veenat may also be consumed to control cancer from increasing in patients, after surgical removal of gist.

MOQ 120 Cap

Imatinib Mesylate(100mg) Uses Veenat 100 mg capsule is used in the treatment of blood cancer (chronic myeloid leukaemia)How it works Veenat 100 mg capsule In patients with cancer, a change in DNA (genetic material) triggers a signal which produces abnormal cancer cells. Veenat 100 mg capsule blocks this signal, and thus stops the production of these cancer cells.Common side effects Nausea, Rash, Vomiting, Musculoskeletal pain, Edema, Abdominal pain, Fatigue, Diarrhoea, Muscle cramp

1 strip * 10 capsules

• Delivery Time: 10 to 14 days

Uses Revolade 25 mg tablet is used in the treatment of chronic idiopathic thrombocytopenia How it work sRevolade 25 mg tablet belongs to class of drugs called anti hemorrhagics. It works by activating the production and proliferation of platelets from bone marrow.Common side effects Nausea, Running nose, Back pain, Rash, Muscle pain, Mouth ulcer, Musculoskeletal pain, Oropharyngeal pain, Fever, Upper respiratory tract infection, Nasopharyngitis, Paresthesia (tingling or pricking sensation), Hair loss, Dry eye, Cough, Toothache, Increased liver enzymes, Menorrhagia (heavy menstrual bleeding), Bone pain, Diarrhoea, Muscle cramp

1 strip = 7 tablets 

We are the leading supplier of DASAKAST DASATINIB TABLETS 50 MG made available to our clients at competitive prices.

Naivex is an antiviral drug designed to treat HIV-1 infection in adults and children 12 years of age and weighing 40 kg or more as part of combination antiretroviral therapy. The drug is recommended for use in patients who have not received therapy ("naive"), and in patients with HAART. In some cases, it can be used in patients with partial resistance to integrase inhibitors.

Manufacturer - Hetero Ltd, India. The active substance is Dolutegravir. Dolutegravir in 2013-2014 is approved in many countries of the world as one of the components of highly active antiretroviral therapy, such as the USA, Canada, Mexico, Brazil, the EU, Russia, Japan, Australia, South Africa.

Dolutegravir user guide

 

Dolutegravir inhibits HIV integration by binding to the active region of integrase and blocking the chain transfer during the integration of retroviral deoxyribonucleic acid (DNA), which is necessary for the HIV replication cycle. In vitro, dolutegravir is slowly separated from the active site of the wild-type DNA integrase complex (half-life of 71 hours).

Contraindications

- Hypersensitivity reactions to dolutegravir (and auxiliary substances). 
- Admission of anti-arrhythmic drug Dofetilide (English name Tikosyn) 
- Age is less than 12 years and body weight is less than 40 kg

Dolutegravir is rapidly absorbed after ingestion. The average time to reach the maximum concentration is 2-3 hours. When you take 1 time per day, the pharmacokinetic steady state is reached approximately 5 days after the beginning of the oral administration. Food increases the degree and reduces the rate of absorption of dolutegravir. These changes are generally clinically insignificant, so Instgra can be taken regardless of food intake. However, patients infected with HIV-1 with a certain resistance to integrase inhibitors are advised to take Naivex with food.

Co-infection with hepatitis C does not matter for the pharmacokinetics of dolutegravir. Data on co-infection with hepatitis B are limited.

Side effects

 

- Impaired immune system. Infrequently: a hypersensitivity reaction, a syndrome of a restoration of immunity. 
- Disorders of the psyche. Often: insomnia. 
- Disorders of the nervous system. Very often: a headache. Often: dizziness, unusual dreams. 
- Disorders of the digestive tract. Very often: nausea, diarrhea. Often: vomiting, flatulence, pain in the upper abdomen. Infrequent: pain in the abdomen, discomfort in the abdomen. 
- Disorders of the liver and biliary tract. Infrequently: hepatitis. 
- Impaired skin and subcutaneous tissue. Often: rash, itching. General disorders and disorders at the site of administration. Often: fatigue.

Interaction

- The simultaneous use of dolutegravir and other drugs that inhibit UDP-HT 1A1, UDF-GT1A3, UDF-GT1A9, CYP3A4 and/or Pgp, may increase the concentration of dolutegravir in blood plasma. 
- Contraindicated simultaneous reception with dofetilide. 
- The simultaneous use of dolutegravir and etravirine is not recommended unless the patient receives simultaneously atazanavir/ritonavir, lopinavir/ritonavir or darunavir/ritonavir. 
- The drug should not be administered together with antacids containing polyvalent cations. It is recommended to use dolutegravir 2 hours before or 6 hours after the application of these agents. 
- Dolutegravir may increase the concentrations of metformin. It is necessary to monitor patients during therapy, and metformin dosages may need to be adjusted.

 

Keep the drug in a dry place, protected from sun and inaccessible to children, at a temperature of 15 to 30 ° C. Date of manufacture and shelf life are indicated on the packaging.

• Delivery Time: 7 t0 14 Days

Other Details:

• Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys)
• Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine
• Sorafenib is in a class of medications called kinase inhibitors
• It works by blocking the action of an abnormal protein that signals cancer cells to multiply
• This helps stop the spread of cancer cells

Uses Erlotinib is used in the treatment of pancreatic cancer and small cell lung cancer How it works Erlotinib belongs to a class of medications called tyrosine kinase inhibitors. It works by preventing the activity of a protein called epidermal growth factor, and thereby stops the growth and spread of cancer cells.Common side effects Nausea, Neuropathy, Nail disorder, Rash, Abdominal pain, Abnormal liver function tests, Acne, Change in body weight, Conjunctivitis, Cough, Depression, Diarrhoea, Dry skin, Shortness of breath, Fatigue, Flatulence, Flushing, Inflammation of hair follicles, Gastrointestinal bleeding, Gastrointestinal disturbance, Hair loss, Headache, Indigestion, Infection, Itching, Decreased white blood cell count, Loss of appetite, Respiratory disorder, Feeling of cold, Skin fissures, Stomatitis, Vomiting

TUDOFOVIR

(Tenofovir Disoproxil Fumarate Tablets IP)

COMPOSITION

Each film coated tablet contains:

Tenofovir Disoproxil Fumarate IP 300 mg

Colours : Indigo Carmine & Titanium Dioxide.

PHARMACOLOGY

Tenofovir disoproxil fumarate is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir disoproxil fumarate requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate. Tenofovir diphosphate inhibits the activity of HIV-1 reverse transcriptase by competing with the natural substrate deoxyadenosine 5`-triphosphate and, after incorporation into DNA, by DNA chain termination. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase gamma.

PHARMACOKINETICS

The pharmacokinetics of tenofovir disoproxil fumarate has been evaluated in healthy volunteers and HIV-1 infected individuals. Tenofovir pharmacokinetics is similar between these populations.

Absorption: Tenofovir disoproxil fumarate is a water soluble diester prodrug of the active ingredient tenofovir. The oral bioavailability of tenofovir from tenofovir disoproxil fumarate in fasted patients is approximately 25%. Following oral administration of a single dose of tenofovir disoproxil fumarate 300 mg to HIV-1 infected patients in the fasted state, maximum serum concentrations (C max ) are achieved in 1.0 ± 0.4 hrs. C max and AUC values are 296 ± 90 ng/mL and 2287 ± 685 ng·hr/mL, respectively.

The pharmacokinetics of tenofovir are dose proportional over a tenofovir disoproxil fumarate dose range of 75 to 600 mg and are not affected by repeated dosing.

Effects of Food on Oral Absorption: Administration of tenofovir disoproxil fumarate following a high-fat meal (~700 to 1000 kcal containing 40 to 50% fat) increases the oral bioavailability, with an increase in tenofovir AUC of approximately 40% and an increase in C max of approximately 14%. However, administration of tenofovir disoproxil fumarate with a light meal did not have a significant effect on the pharmacokinetics of tenofovir when compared to fasted administration of the drug. Food delays the time to tenofovir C max by approximately 1 hour.

Distribution: In vitro binding of tenofovir to human plasma or serum proteins is less than 0.7 and 7.2%, respectively, over the tenofovir concentration range 0.01 to 25 μg/mL. The volume of distribution at steady state is 1.3 ± 0.6 L/kg and 1.2 ± 0.4 L/kg, following intravenous administration of tenofovir 1.0 mg/kg and 3.0 mg/kg.

Metabolism and Elimination: In vitro studies indicate that neither tenofovir disoproxil nor tenofovir are substrates of CYP450 enzymes.

Following IV administration of tenofovir, approximately 70-80% of the dose is recovered in the urine as unchanged tenofovir within 72 hours of dosing. Following single dose, oral administration of tenofovir disoproxil fumarate, the terminal elimination half-life of tenofovir is approximately 17 hours. After multiple oral doses of tenofovir disoproxil fumarate 300 mg once daily (under fed conditions), 32 ± 10% of the administered dose is recovered in urine over 24 hours.

Tenofovir is eliminated by a combination of glomerular filtration and active tubular secretion.

INDICATIONS : TUDOFOVIR is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.

• Delivery Time: 7 to 10 Days

Temirazer is a far-reaching powerful antiretroviral sedate for the treatment of HIV-1 and HIV-2 contaminations in patients more than 18 years old. Can be taken correspondingly with other comparative medications. Temirazer is doled out to a gathering of non-nucleoside inhibitors with turnaround transcriptase, otherwise called a protease inhibitor. The medication contains two fundamental dynamic fixings - tenofovir and emtricitabine, because of which the medication has a viable impact in the battle against HIV contaminations, keeping the infection from spreading in the host's body.

It ought to be noticed that Temirazer does not totally keep the danger of HIV transmission, but rather is a successful method to anticipate it. After various investigations in the United States, it has been demonstrated that this medication helps battle AIDS, and on the off chance that it is clung to, the danger of contracting HIV is decreased by 73%. It is additionally realized that Temirazer is an inhibitor of the hepatitis B infection, yet it isn't prescribed to utilize the medication with its endless shape. In the wake of finishing the course of taking Temirazer, individuals with HIV and ceaseless hepatitis B ought to be checked by their specialist inside a couple of months. 

• Delivery Time: 7 to 14 Days

Uses:- Nublexa contains the active substance regorafenib.
Nublexa Regorafenib is a medicine used to treat cancer by slowing down the growth and spread of cancer cells and cutting off the blood supply that keeps cancer cells growing.
Nublexa is a multikinase inhibitor (MKI) that targets cancer growth and progression by inhibiting multiple protein kinase.
Treatment with Nublexa has shown to improve survival in patients with colorectal cancer and advanced gastrointestinal stromal tumour (GIST) who have been previously treated with 2 tyrosine kinase inhibitors.

Side Effects:- Diarrhea , dry mouth , weight loss n weakness , headache.

Uses Revolade 50 mg tablet is used in the treatment of chronic idiopathic thrombocytopenia How it works Revolade 50 mg tablet belongs to class of drugs called antihemorrhagics. It works by activating the production and proliferation of platelets from bone marrow.Common side effects Nausea, Running nose, Back pain, Rash, Muscle pain, Mouth ulcer, Musculoskeletal pain, Oropharyngeal pain, Fever, Upper respiratory tract infection, Nasopharyngitis, Paresthesia (tingling or pricking sensation), Hair loss, Dry eye, Cough, Toothache, Increased liver enzymes, Menorrhagia (heavy menstrual bleeding), Bone pain, Diarrhoea, Muscle cramp

1 strip(s) (7 tablets

Uses Aromasin 25 mg tablet is used in the treatment of breast cancer How it works Aromasin 25 mg tablet works by decreasing the amount of estrogen (natural female hormone) produced in the body. This can slow or stop the growth of some breast cancer that need estrogen to grow. Common side effects Joint pain, Headache, Insomnia, Musculoskeletal pain, Nausea, Increased sweating, Fatigue, Hot flushes

1 strip(s) (15 tablets)

Other Details:

• Pazopanib (trade name Votrient) is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis
• It has been approved for renal cell carcinoma and soft tissue sarcoma by numerous regulatory administrations worldwide

Uses Evertor 10mg tablet is used in breast cancer, pancreatic cancer, lung cancer and kidney cancer
How it works Evertor 10mg tablet suppresses the activity of body’s immune system and prevents rejection of the transplanted organ.
Common side effects Acne, Altered taste, Dry mouth, Dry skin, Hair loss, Headache, Insomnia, Nail disorder, Nose bleed, Weakness, Weight loss, Constipation, Diarrhoea

1 strip(s) (10 tablets)

Capecitabine is used

Treating certain types of breast, colon, or colorectal cancer in some patients. It may be used alone or with other medicines in some cases.

Capecitabine is an antimetabolite. It works by interfering with the production of proteins necessary for cancer cell growth and reproduction.

Do NOT use capecitabine if:

• you are allergic to any ingredient in capecitabine or to 5-fluorouracil
• you have severe kidney problems or you have been told that you lack the enzyme dihydropyrimidine dehydrogenase (DPD)

Contact your doctor or health care provider right away if any of these apply to you.

Before using capecitabine:

Some medical conditions may interact with capecitabine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription (particularly blood thinners) or nonprescription medicine, herbal preparation, or dietary supplement (vitamin E, aspirin, ibuprofen, naproxen)
• if you have allergies to medicines, foods, or other substances
• if you have a history of heart, kidney, or liver problems; bone marrow problems; or pain, redness, swelling, tingling, or tenderness of the palms of the hands or soles of the feet (hand-and-foot syndrome)
• if you have nausea, vomiting, diarrhea, inflammation or sores in the mouth, or an infection
• if you are undergoing chemotherapy or radiation therapy, or if you take folic acid or vitamins that contain folic acid

Some MEDICINES MAY INTERACT with capecitabine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Certain anticoagulants (eg, phenprocoumon, ) because the risk of bleeding may be increased by capecitabine
• Leucovorin because the risk of severe intestinal problems, diarrhea, and dehydration may be increased
• Hydantoins (eg, phenytoin) because their side effects may be increased by capecitabine

This may not be a complete list of all interactions that may occur. Ask your health care provider if capecitabine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use capecitabine:

Use capecitabine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with capecitabine. Talk to your pharmacist if you have questions about this information.
• Take capecitabine with food or within 30 minutes after a meal.
• Swallow capecitabine whole with water. Do not break, crush, or chew before swallowing.
• It is recommended to use gloves and safety glasses to avoid exposure in case a tablet breaks. If powder from a broken tablet comes into contact with skin, wash the skin immediately with soap and water. If powder comes into contact with your mouth, nose, or eyes, rinse thoroughly with water.
• If you miss a dose of capecitabine, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Check with your doctor if you miss a dose.

Ask your health care provider any questions you may have about how to use capecitabine.